Stay in a business hotel over the weekend.
If I MUST stay in a hotel, I try to find those in the business area where I am visiting. Their rates often dip on weekends and they have great amenities. I stayed in New Orleans on several trips and was able to score some nice hotels in the “Business District“, a great location outside of the insane Bourbon Street area. There were great restaurants and it was just a short walk to all the liveliness of New Orleans. It was also perfectly situated in close proximity to the trolley and actually was in a center location relative to all the city has to offer.